Añadir referencia a la autora original del script sobre el que estamos modificando.

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 ## This functions are adapted from Zoe Moodie version.
 ## https://rundfr.fredhutch.org/
 ## https://www.fredhutch.org/content/dam/www/research/divisions/vaccine-infectious-disease-division/staff-scientists/moodie/elsdfreq.R
 ############
 ## REFERENCE:
 ## Cancer Immunol Immunother. 2010 Oct; 59(10): 1489.1501.
 ## doi: 10.1007/s00262-010-0875-4
 ## PMCID: PMC2909425
 ## Response definition criteria for ELISPOT assays revisited
 ## Z. Moodie, L. Price, C. Gouttefangeas, A. Mander, S. Janetzki, M. Loewer, M. J. P. Welters, C. Ottensmeier, S. H. van der Burg, and Cedrik M. Britten
 impose.mono <- function(x, dir){
  # Function to impose monotonicity on elements of the vector, x
  # dir="incr" gives increasing monotonicity